Pyridoxine disulfide or pyrithioxine or pyritinol

Application Capsaicin has been used: to study its effects on chromatin remodeling and gene expression related to synaptic plasticity to study TRPV1 channel signaling in H2C1 cells (which are human embryonic kidney 293 cells expressing TRPV1

General description A neurotoxin that acts as an antagonist of voltage-activated N-type Ca 2+ channels and of neurotransmitter release at neuronal synapses. Its antagonistic activity is attributed to a tyrosine residue at position 13.

Dimethyl 1H-pyrrole-2,4-dicarboxylate.

Application dPPA/phorbol ester 12-deoxyphorbol 13-phenylacetate 20-acetate (DOPPA) may be used as a potent activator of PKC-&#946: to treat transfected HT-22 cells to promote phosphorylation of p66Shc to treat HT-22 and B12 cells to study its

DYRK1-IN-1 is a highly selective and ligand-efficient DYRK1A inhibitor. DYRK1-IN-1 inhibits DYRK1A phosphorylation activity with an IC 50 value of 220 nM. DYRK1-IN-1 can be used for the research of central nervous system penetrant DYRK1A chemical

DYRK1-IN-1 is a highly selective and ligand-efficient DYRK1A inhibitor. DYRK1-IN-1 inhibits DYRK1A phosphorylation activity with an IC 50 value of 220 nM. DYRK1-IN-1 can be used for the research of central nervous system penetrant DYRK1A chemical

A useful derivative for the synthesis of phosphotyrosine peptides [1,2,3,4,5,67] by Fmoc SPPS. Pyrophosphate formation has been noted in peptides containing adjacent Tyr(PO 3 H 2 ) residues [4,5] .

A cell-permeable mycotoxin that inhibits sphingolipid biosynthesis in rat kidney and in liver microsomes by inhibition of sphingosine N-acyltransferase (ceramide synthase IC 50 = 100 nM). Preferentially inhibits sphingomyelin biosynthesis in

Gliotoxin

Gliotoxin

Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3.

Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3.