MI-2-2 (C008B-268547)

MI-2-2 is a potent menin-MLL inhibitor. MI-2-2 binds to menin with low nanomolar affinity (K d =22nM) and very effectively disrupts the bivalent protein-protein interaction between menin and MLL. MI-2-2 has specific and very pronounced activity in MLL leukemia cells, including inhibition of cell proliferation, down-regulation of Hoxa9 expression, and differentiation.In VitroMI-2-2 is capable of inhibiting both the interaction of menin with MBM1 (IC 50 = 46 nM) and with the bivalent fragment of MLL that comprises both MBM1 and MBM2 (IC 50 =520 nM). MI-2-2 exhibits very pronounced activities at low micromolar concentrations in BMCs transformed with MLL-AF9 and in MV4;11, a human leukemia cell line harboring the MLL-AF4 translocation. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:Solid

Specifications & Purity: MI-2-2 is a potent menin-MLL inhibitor. MI-2-2 binds to menin with low nanomolar affinity (K d =22nM) and very effectively disrupts the bivalent protein-protein interaction between menin and MLL. MI-2-2 has specific and very pronounced activity in MLL leukemia cells, including inhibition of cell proliferation, down-regulation of Hoxa9 expression, and differentiation.In VitroMI-2-2 is capable of inhibiting both the interaction of menin with MBM1 (IC 50 = 46 nM) and with the bivalent fragment of MLL that comprises both MBM1 and MBM2 (IC 50 =520 nM). MI-2-2 exhibits very pronounced activities at low micromolar concentrations in BMCs transformed with MLL-AF9 and in MV4;11, a human leukemia cell line harboring the MLL-AF4 translocation. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:Solid

Grade: Moligand™

Molecular Formula: C17H20F3N5S2

Molecular Weight: 415.50

Storage Temperature: Protected from light;Store at -20°C;Argon charged;Desiccated

Shipped in: Ice chest + Ice pads

UPC:

51433503

Weight:

1.06 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

M647167-50mg

Country of Origin:

China

CAS:

1454920-20-7

Product Size:

50mg

Harmonized Tariff Code:

2931.90.90