Milli-Mark Anti-CD10-FITC Antibody, clone SS2/36

General description

CD10 is a 100 kDa protein belonging to a family of type II transmembrane metalloproteases which also includes the leukocyte antigens CD13, CD26, CD73 and aminopeptidase. The gene encoding CD10 is located on chromosome 3. CD10 is a zinc-dependent enzyme and is thought to down-regulate cellular responses to peptide hormones (Barclay, 1997). On lymphoid cells, CD10 is expressed on immature T and B precursor cells but is lost as the cells reach maturation. CD10 is, however, re-expressed on proliferating B cells and mature neutrophils (Jones, 1997). Anti-CD10, SS2/36, was included in the Third International Workshop and Conference on Human Leucocyte Differentiation Antigens, and studies by a number of laboratories confirmed its reactivity with CD 10 (Majdic, 1987).

Specificity

Antibody recognizes Human CD10 antigen.

Immunogen

Acute lymphoblastic leukemia cells

Application

Milli-Mark Anti-CD10-FITC Antibody, clone SS2/36 detects level of CD10 & has been published & validated for use in FC.

Research Category
Inflammation & Immunology

Research Sub Category
Immunoglobulins & Immunology

Quality

Evaluated by flow cytometry using human PBMCs

Target description

100 kDa (Barclay, 1997)

Physical form

Protein A purified

Purified Mouse monoclonal IgG1 conjugated to FITC in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.

Storage and Stability

Maintained refrigerated at 2-8°C from date of receipt. Protected from light in undiluted aliquots for 6 months from date of receipt.

Analysis Note

Control
PBMCs

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.