MK-0429

MK-0429 (L-000845704) is an orally active, potent, selective and nonpeptide pan-integrin antagonist with IC 50 values of 1.6 nM, 2.8 nM, 0.1 nM, 0.7 nM, 0.5 nM and 12.2 nM for αvβ1 , αvβ3 , αvβ5 , αvβ6 , αvβ8 and α5β1 , respectively .In VivoMK-0429 (100 or 300 mg/kg, p.o., twice daily b.i.d., 2 weeks) reduces metastatic tumor colony formation and area in the lungs. MK-0429 is safe and efficacious in significantly decreasing melanoma metastasis in the lungs . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: B6D2F1 hybrid female miceDosage: 100 or 300 mg/kg Administration: P.o., twice daily (b.i.d.), 2 weeks Result: MK-0429 at 100 and 300 mg/kg reduced the number of metastatic tumor colonies by 64 and 57%, respectively, and the high dose also reduced the tumor area by 60% as compared to the vehicle.Form:Solid

Specifications & Purity: MK-0429 (L-000845704) is an orally active, potent, selective and nonpeptide pan-integrin antagonist with IC 50 values of 1.6 nM, 2.8 nM, 0.1 nM, 0.7 nM, 0.5 nM and 12.2 nM for αvβ1 , αvβ3 , αvβ5 , αvβ6 , αvβ8 and α5β1 , respectively .In VivoMK-0429 (100 or 300 mg/kg, p.o., twice daily b.i.d., 2 weeks) reduces metastatic tumor colony formation and area in the lungs. MK-0429 is safe and efficacious in significantly decreasing melanoma metastasis in the lungs . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: B6D2F1 hybrid female miceDosage: 100 or 300 mg/kg Administration: P.o., twice daily (b.i.d.), 2 weeks Result: MK-0429 at 100 and 300 mg/kg reduced the number of metastatic tumor colonies by 64 and 57%, respectively, and the high dose also reduced the tumor area by 60% as compared to the vehicle.Form:Solid

Grade: Moligand™

Molecular Formula: C23H29N5O4

Molecular Weight: 439.51

EC Number: 836-017-2

PubChem CID: 9853559

Isomeric SMILES: COC1=NC=C(C=C1)[C@H](CC(=O)O)N2CCN(C2=O)CCCC3=NC4=C(CCCN4)C=C3

Storage Temperature: Store at -20°C

Shipped in: Ice chest + Ice pads

UPC:

51442705

Weight:

1.06 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

M648007-1mg

Country of Origin:

China

CAS:

227963-15-7

Product Size:

1mg

Harmonized Tariff Code:

2931.90.90