MMP-2/MMP-7 SUBSTRATE FLUOROGENIC - CALBIOCHEM

General description

Extremely sensitive fluorogenic substrate for matrix metalloproteinases (MMPs). Suitable for assessment of total activity in crude preparations by continuous assays (k_cat/K_m = 1.7 x 10⁵ M^-1sec^-1 for MMP-7 and 6.3 x 10⁵ M^-1sec^-1 for MMP-2).

Biochem/physiol Actions

Cell permeable: no

Primary Target
Fluorogenic substrate for matrix metalloproteinases (MMPs)

Product does not compete with ATP.

Reversible: no

kcat/Km = 1.7 x 105 M-1sec-1 for MMP-7 and 6.3 x 105 M⁻¹ sec⁻¹ for MMP-2

Warning

Toxicity: Standard Handling (A)

Sequence

MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH₂ ·TFA [Dpa = N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Knight, C.G., et al. 1992. FEBS Lett. 296, 263.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

UPC:

41181929

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

MPN:

03-32-5032-1MG