General description
A tetrapeptidyl hydroxamic acid that inhibits MMP-1 and MMP-8 (IC50 = 1.0 µM), MMP-9 (IC50 = 30 µM) and MMP-3 (IC50 = 150 µM). Retains its activity even after prolonged incubation with PRONASE
A tetrapeptidyl hydroxamic acid that inhibits interstitial and granulocyte collagenases (MMP-1 and MMP-8; IC50 = 1 µM), granulocyte gelatinase (MMP-9; IC50 = 30 µM), adn skin fibroblast stromelysin (MMP-3; IC50 = 150 µM). Retains its activity even after prolonged incubation with PRONASE
Biochem/physiol Actions
Cell permeable: no
Primary Target
MMP-1, MMP-8
Product does not compete with ATP.
Reversible: no
Warning
Toxicity: Standard Handling (A)
Sequence
4-Abz-Gly-Pro-D-Leu-D-Ala-NH-OH [Abz = aminobenzoyl]
Reconstitution
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Other Notes
Hagemamn, T., et al. 2004. Carcinogenesis25, 1543.
Odake, S., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1442.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Molecular Weight: 490.55. Empirical Formula: C23H34N6O6. Quality Level: 100. Assay: ≥. 98% (HPLC). form: solid. potency: 1 . μ. M IC50. manufacturer/tradename: Calbiochem®. . storage condition: OK to freeze. color: white. solubility: water: 1 . mg/mL. shipped in: ambient. storage temp.: −. 20°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.- UPC:
- 51111726
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 444250-10MG