MMP13-IN-2 (C007B-375479)

MMP13-IN-2 is a potent, selective and orally active MMP-13 inhibitor. MMP13-IN-2 exhibits excellent potency for MMP-13 ( IC 50 =0.036 nM) and selectivities (greater than 1,500-fold) over MMP-1 , 3, 7, 8, 9, 14, and TACE. MMP13-IN-2 has the ability to block the release of collagen from cartilage in vitro. MMP13-IN-2 has the potential for collagenase related disease researchIn VitroIn a bovine nasal cartilage (BNC) assay, the chondrocyte-mediated degradation of cartilage was studied using bovine nasal cartilage slices cultured for up to 14 days. MMP13-IN-2 (0.01-1 µM) is effective at preventing the IL-1/OSM induced in vitro degradation of BNC (-17.6%, 48.4% and 70.8% inhibition of cartilage degradation, respectively).. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoMMP13-IN-2 (oral gavage; 1 mg/kg) shows the best combination of CYP3A4 inhibition risk and oral exposure at a dose of 1 mg/kg in rats and mice (F% = 33 and 38, respectively) . MCE has not independently confirmed the accuracy of these methods. They are for reference only.IC50& Target:MMP-13 0.036 nM (IC 50 ) MMP-2 180 nM (IC 50 ) MMP-3 1100 nM (IC 50 ). Specification: 10mM in DMSO Molecular Formula: C24H19FN6O4S Molecular Weight: 506.51

UPC:

41181544

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

M655115-1ml

CAS:

935759-55-0

Product Size:

1ml