Molecular Biology Reagents

A specific and reversible inhibitor of CPP32/Apopain/Yama (IC 50 = 0.2 nM).

A fluorogenic substrate for caspase-6 (Mch2). Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore (excitation maximum: ~400 nm emission maximum: ~505 nm).

A potent, cell-permeable, and irreversible inhibitor of caspase-8 (MACH, FLICE, Mch5). Also inhibits granzyme B.

A potent, cell-permeable, and irreversible inhibitor of caspase-8 (MACH, FLICE, Mch5). Also inhibits granzyme B.

OR Grade Premium surgical Instruments, Germany Stainless

A potent, selective, reversible, and competitive non-peptide inhibitor of cathepsin G (IC 50 = 53 nM and K i = 63 nM). Weakly inhibits chymotrypsin (K i = 1.

A potent, selective, reversible, and competitive non-peptide inhibitor of cathepsin G (IC 50 = 53 nM and K i = 63 nM). Weakly inhibits chymotrypsin (K i = 1.

Cysteine protease inhibitor. Selectively inhibits cathepsin B (k 2 /K i = 1 x 10 4 M -1 sec -1 ), cathepsin L (k 2 /K i = 1.

A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (K i,app = 6 nM). Shown to completely block cathepsin K activity in primary human synovial fibroblast cultures at 1

A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (K i,app = 9.7 nM).

A cell-permeable, allosteric, trisubstituted dihydropyrazolyl compound that acts as a potent, selective, reversible and non-competitive inhibitor of Cdc42 GTPases (IC 50 = 0.2, 2.

A potent, reversible, and substrate-competitive inhibitor of Cdk4/cyclin D1 (IC 50 = 200 nM). Displays ~500-fold greater selectivity for Cdk4/cyclin D1 over Cdc2/cyclin A (Cdk1/cyclin A), Cdk2/cyclin A, and Cdk2/cyclin E (IC 50 &gt100 &#181M).