Phospholipase Inhibitors

An irreversible general caspase inhibitor. Useful for studies involving recombinant, isolated, and purified caspase enzymes.

An irreversible general caspase inhibitor. Useful for studies involving recombinant, isolated, and purified caspase enzymes.

A highly selective, competitive, cell-permeable, and irreversible inhibitor of caspase-1, caspase-4, and caspase-5. Inactivates the enzyme with a rate limited by diffusion and is relatively inert toward other bionucleophiles such as glutathione,

An enhanced cell-permeable, non-toxic, orally available masked aspartaldehyde prodrug that is converted to its active metabolite, VRT-043198, both in vitro and in vivo via hydrolytic cleavage by esterases. The active metabolite displays anti-

A specific and reversible inhibitor of CPP32/Apopain/Yama (IC 50 = 0.2 nM).

A specific and reversible inhibitor of CPP32/Apopain/Yama (IC 50 = 0.2 nM).

A fluorogenic substrate for caspase-6 (Mch2). Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore (excitation maximum: ~400 nm emission maximum: ~505 nm).

A potent, cell-permeable, and irreversible inhibitor of caspase-8 (MACH, FLICE, Mch5). Also inhibits granzyme B.

A potent, cell-permeable, and irreversible inhibitor of caspase-8 (MACH, FLICE, Mch5). Also inhibits granzyme B.

A cell-permeable and specific activator of phospholipase C (PLC). Reported to stimulate PLC-mediated intracellular Ca 2+ release, inositol phosphate production, and superoxide generation in various cell types.

PrEST Antigen APPL2 adaptor protein, phosphotyrosine interac

PrEST Antigen PID1 phosphotyrosine interaction domain contai