MPI-0479605 (C007B-231379)

InformationMPI-0479605 MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases.TargetsMps1 1.8 nMIn vitroMPI-0479605 impairs the SAC and the bipolar attachment of chromosomes to the mitotic spindle, which results in chromosome segregation defects and aneuploidy. MPI-0479605 results in a significant decrease in cell viability with GI50 ranging from 30 to 100 nM in a panel of tumor cell lines. In addition, MPI-0479605 also causes cell growth arrest and ultimately promotes cell death by apoptosis or mitotic catastrophe.In vivoMPI-0479605 (30 mg/kg daily or 150 mg/kg every 4 days, i.p.) shows antitumor activity in colon cancer xenograft models.Cell Research(from reference)Cell lines：A549, Colo205, DU-4475, DU-145, HCC827, HCT116, HT29, MDA MB 231, MiaPaCa2, NCI-H69, NCI-H460, NCI-N87, OPM2, and OVCAR-3 cells. Concentrations：~10 μM Incubation Time：3 or 7 days. Specification: 10mM in DMSO Molecular Formula: C22H29N7O Molecular Weight: 407.51 PubChem CID: 46909588 Isomeric SMILES: CC1=C(C=CC(=C1)N2CCOCC2)NC3=NC4=C(C(=N3)NC5CCCCC5)NC=N4

UPC:

51112702

Condition:

New

Weight:

0.85 Ounces

HazmatClass:

No

WeightUOM:

LB

MPN:

M421046-1ml

CAS:

1246529-32-7

Product Size:

1ml