MS117 (C007B-375924)

MS117 is a first-in-class and cell-active irreversible protein arginine methyltransferase 6 (PRMT6) covalent inhibitor, with an IC 50 of 18 nM.IC50& Target:IC50: 18 nM (PRMT6), 100 nM (PRMT1), 110 nM (PRMT8), 3 μM (PRMT3), 4 μM (PRMT4) .In Vitro:MS117 (Compound 4) inhibits the PRMT6 methyltransferase activity in a time-dependent manner. MS117 (Compound 4) shows moderate selectivity (6-fold) for PRMT6 over PRMT1 (IC 50 = 0.1 ± 0.025 µM) and PRMT8 (IC 50 = 0.11 ± 0.01 µM). MCE has not indBiological Activity:MS117 is a first-in-class and cell-active irreversible protein arginine methyltransferase 6 (PRMT6) covalent inhibitor, with an IC 50 of 18 nM. Specification: 10mM in DMSO Molecular Formula: C17H22N4O Molecular Weight: 298.38

UPC:

51112708

Condition:

New

Weight:

1.09 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

M661708-1ml

Product Size:

1ml