MYOVIN-1 1PC X 5MG (C005B-228264)

General description

A pyrazolopyrimidine compound that blocks ADP release from the actomyosin complex and acts as a potent, reversible and uncompetitive inhibitor of actin-stimulated ATPase activity of myosin V (K_i = 6.3 and 5.5 µM by single- and double-headed myosin V). Displays excellent selectivity over myosin II and myosin IV (<10% inhibition at 50 µM) and only minimally inhibits the kinase activity of Cdk1/B, CHK1, Plk1, Abl, ERK2, CKII and Aurora-B (<10% inhibition at 100 µM).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Islam, K., et al. 2010. Angew. Chem. Int. Ed.49, 8484.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Molecular Weight: 538.62. Empirical Formula: C₂₉H₂₆N₆O₃S. Quality Level: 100. Assay: ≥. 95% (HPLC). form: powder. manufacturer/tradename: Calbiochem^®. . storage condition: OK to freeze, protect from light. color: pale yellow. solubility: DMSO: 50 . mg/mL. shipped in: ambient. storage temp.: −. 20°C. SMILES string: O: C(C1: CC: CC(SCC2: CC: CC(NC3: NC(NN: C4C5: CC: C(N6CCOCC6)C: C5): C4C: N3): C2): C1)O. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.

Shipping Information:

Dry Ice Surcharge & Ice Pack Shipments: $40

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UPC:

51111651

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

Quantity:

5

Unit of Measurement:

MG

MPN:

475984-5MG

Temperature Control Device:

Yes