N-BUTYLLITHIUM SOLUTION 2.5 M IN HEXANES (C005B-007439)

General description

n-Butyllithium (n-BuLi) is an organolithium reagent commonly used as a strong base in organic synthesis. It is also used as a lithium source for a wide range of lithium bases, such as lithium amides, acetylides, and alkoxides.

Application

n-BuLi can be used as a strong base to form corresponding lithium salts by the deprotonation of nitrogen, oxygen, phosphorus, and carbon acids. Heterocyclic compounds, such as furans, thiophenes, oxazoles, pyrroles, etc, can be lithiated α to the ring heteroatom using n-BuLi. These lithiated salts react in situ with alkyl halides to obtain useful organic compounds by the formation of the C-C bond. n-BuLi is also a useful reagent for lithium€“halogen exchange reactions. Synthesis of various other useful reagents such as lithium diisopropylamide (LDA) and diphenylphosphine is done by in situ reaction with n-BuLi In the polymerization of dienes, n-BuLi is employed as an initiator.
The product is also used in the following reactions:      

• Anionic rearrangement reactions      
• Metal-halogen interchange and transmetalation reactions
• Elimination reactions      
• [1,2]- and [1,4]-Wittig rearrangement reaction      
• Anionic homo-Fries rearrangement reaction      
• Asymmetric carbolithiation

Packaging

The 25 mL Sure/Seal^™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.

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Legal Information

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

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UPC:

51131627

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

Yes

Quantity:

100

Unit of Measurement:

ML

MPN:

230707-100ML

CAS:

109-72-8

Temperature Control Device:

Yes