Nelonicline (C007B-378419)

Nelonicline (ABT-126) is an orally active and selective α7 nicotinic receptor agonist with high affinity to α7 nAChRs in human brain ( K i =12.3 nM). Nelonicline is used for the research of shizophrenia and Alzheimer's diseaseIn VitroNelonicline is an agonist that binds with high affinity to α7 nAChRs in human brain (K i = 12.3 nM) and activates currents in Xenopus oocytes expressing recombinant human α7 nAChRs (EC 50 =2 μM; intrinsic activity of 74% relative to acetylcholine). Nelonicline does bind to α3β4* nAChRs in human IMR-32 neuroblastoma cells (K i =60 nM), but has only 12% efficacy at 100,000 nM in a calcium flux assay in these cell. Like some other α7 nAChR agonists, Nelonicline is also a 5-HT3 receptor antagonist, but it has >10-fold lower affinity for this receptor than for α7 nAChRs (K i of 140 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:Neuronal nicotinic receptor. Specification: 0.99 Molecular Formula: C17H19N3OS Molecular Weight: 313.42 PubChem CID: 24987875 Isomeric SMILES: C1C2CC3CN(C2)CC1C3OC4=NN=C(S4)C5=CC=CC=C5

UPC:

51143015

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

N646910-10mg

CAS:

1026134-63-3

Product Size:

10mg