NICLOSAMIDE (C005B-444344)

Application

Niclosamide is a teniacide in the anthelmintic family. It is effective against cestodes that infect humans. Niclosamide is used to study the Wnt/Frizzled-1 signaling pathway. It is used to inhibit transcription and DNA binding of the NF-?B pathway and it increases ROS levels to induce apoptosis in acute myelogenous leukemia (AML) cells.

Biochem/physiol Actions

Niclosamide uncouples oxidative phosphorylation in the tapeworm and inhibits mitochondrial oxidative phosphorylation of parasitic helminths. It blocks tumor necrosis factor-induced IκBα phosphorylation, translocation of p65, and expression of NF-κΒ€“ regulated genes in AML cells.

Other Notes

50g,250g

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

UPC:

51451907

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

Quantity:

250

Unit of Measurement:

GM

MPN:

N3510-250G

CAS:

50-65-7