General description
A dihydroquinilone-pyrazoline NMDA antagonist, which is selective for NMDA receptors that are comprised of recombinant subunits GluN1/GluN2C (IC50 = 5.4 µM) and GluN1/GluN2D (2.2 µM) over GluN1/GluN2B (206 µM) and GluN1/ClucN2A (undetectable) in Xenopus oocytes. Similar selectivity is observed in whole-cell HEK patch-clamp assays with IC50 values for GluN2C and GluN2D that are at least 50-fold lower than those for recombinant GluN2A, GluN2B, GluA1, or GluK2-containing receptors. It inhibits NMDA by blocking a conformational change necessary for channel opening and is non-competitive with co-agonists, glutamate and glycine.
Packaging
Packaged under inert gas
Warning
Toxicity: Regulatory Review (Z)
Other Notes
Acker, T., et al. 2011. Mol. Pharmacol.80, 782.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Molecular Weight: 558.42. Empirical Formula: C29H24BrN3O4. Quality Level: 100. Assay: ≥. 97% (HPLC). form: solid. manufacturer/tradename: Calbiochem®. . storage condition: OK to freeze, protect from light. color: yellow-white. solubility: DMSO: 10 . mg/mL, pale yellow. shipped in: ambient. storage temp.: −. 20°C. SMILES string: O: C(O)CCC(N1N: C(C2: C(C3: CC: CC: C3)C4: C(NC2: O)C: CC(C): C4)CC1C5: CC: C(Br)C: C5): O. Storage Class Code: 11 - Combustible Solids. WGK: WGK 2. Flash Point(F): Not applicable. Flash Point(C): Not applicable.- UPC:
- 12352200
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 454586-10MG