Norleual TFA (C007B-379372)

Norleual TFA, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC 50 of 3 pM. Norleual TFA is an AT4 receptor antagonist and exhibits potent antiangiogenic activities.Appearance:SolidIn Vitro:/Norleual TFA at 20 and 50 pM significantly reduces HGF-dependent c-Met and Gab1 phosphorylation. 20 pM Norleual TFA dramatically reduces HGF-initiated association between Gab1 and c-Met in HEK293 cells. Norleual TFA markedly attenuates HGF-dependent c-MeIn Vivo:Norleual TFA (50 μg/kg; intraperitoneal injection; daily; for 2 weeks; C57BL/6 mice) suppresses pulmonary colonization by B16-F10 murine melanoma cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Biological Activity:Norleual TFA, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC 50 of 3 pM. Norleual TFA is an AT4 receptor antagonist and exhibits potent antiangiogenic activities. Specification: 0.99 Molecular Formula: C43H59F3N8O9 Molecular Weight: 888.97

UPC:

51162608

Condition:

New

Weight:

1.09 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

N659268-5mg

Product Size:

5mg