Nrf2-IN-1 (C008B-271514)

Nrf2-IN-1 is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2) . Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML)In VitroNrf2-IN-1 (Compound 4f) (10 μM) inhibits Nrf2 activation. ?\nNrf2-IN-1(1-20 μM; 48 hours) inhibits growth of the three AML cell. ?\nNrf2-IN-1 (5-10 μM; 48 hours) induces apoptosis of three AML cells in vitro. ?\nNrf2-IN-1 induces apoptotic signaling involving Bcl-2 and Bax. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: THP-1 cells, HL-60 cells, U937 cells Concentration: 1 μM, 5 μM, 10 μM, 20 μM Incubation Time: 48 hours Result: Inhibited growth of the three AML cell types at 5 μM, 10 μM or 20 μM for 48 hours. Apoptosis AnalysisCell Line: THP-1 cells, HL-60 cells, U937 cells Concentration: 5 μM, 10 μM Incubation Time: 48 hours Result: Induced apoptosis in AML cells in vitro. Western Blot AnalysisCell Line: THP-1 cells, HL-60 cells, U937 cells Concentration: 5 μM, 10 μM Incubation Time: 48 hours Result: Triggered caspase-dependent apoptotic signaling in AML cells.In VivoNrf2-IN-1 inhibits tumor growth via apoptosis in chicken eggs . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:Nrf2

Specifications & Purity: Nrf2-IN-1 is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2) . Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML)In VitroNrf2-IN-1 (Compound 4f) (10 μM) inhibits Nrf2 activation. ?\nNrf2-IN-1(1-20 μM; 48 hours) inhibits growth of the three AML cell. ?\nNrf2-IN-1 (5-10 μM; 48 hours) induces apoptosis of three AML cells in vitro. ?\nNrf2-IN-1 induces apoptotic signaling involving Bcl-2 and Bax. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: THP-1 cells, HL-60 cells, U937 cells Concentration: 1 μM, 5 μM, 10 μM, 20 μM Incubation Time: 48 hours Result: Inhibited growth of the three AML cell types at 5 μM, 10 μM or 20 μM for 48 hours. Apoptosis AnalysisCell Line: THP-1 cells, HL-60 cells, U937 cells Concentration: 5 μM, 10 μM Incubation Time: 48 hours Result: Induced apoptosis in AML cells in vitro. Western Blot AnalysisCell Line: THP-1 cells, HL-60 cells, U937 cells Concentration: 5 μM, 10 μM Incubation Time: 48 hours Result: Triggered caspase-dependent apoptotic signaling in AML cells.In VivoNrf2-IN-1 inhibits tumor growth via apoptosis in chicken eggs . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:Nrf2

Grade: Moligand™

Molecular Formula: C21H22ClN3O2

Molecular Weight: 383.87

PubChem CID: 76900951

Isomeric SMILES: CC(C)(C)C1=CC=C(C=C1)CN2C(=CC(=N2)C3=CC=C(C=C3)Cl)C(=O)NO

Storage Temperature: Protected from light;Store at -20°C

Shipped in: Ice chest + Ice pads

UPC:

51442005

Weight:

1.06 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

N651953-1mg

Country of Origin:

China

CAS:

1610022-76-8

Product Size:

1mg

Harmonized Tariff Code:

2931.90.90