NRX-103094 (C007B-379142)

NRX-103094 is a potent enhancer of the interaction between β-catenin , and its cognate E3 ligase , SCF β-TrCP . NRX-103094 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC 50 of 62 nM and a K d of 0.6 nMIn VitroNRX-103094 shows high potency with pSer33/Ser37 β-catenin peptide (EC 50 of 457 nM). NRX-103094 potentiates the ubiquitylation of pSer33/S37A β-catenin peptide to levels greater than wild-type pSer33/pSer37 levels at 250 nM. NRX-103094 enhances the S33E/S37A phosphomimetic peptide binding affinity for β-TrCP from >5 μM in the absence of compound to 22 nM in the presence of 40 μM compound. In the presence of 20 μM NRX-103094, robust time-dependent ubiquitylation of S33E/S37A β-catenin peptide is observed. Likewise, the full-length S33E/S37A β-catenin protein is strongly ubiquitylated in the presence of 20 μM NRX-103094, with the ubiquitylation levels approaching that of WT full-length β-catenin protein. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:EC50: 62 nM (β-catenin:β-TrCP Interaction), Kd: 0.6 nM (β-catenin:β-TrCP Interaction). Specification: 0.99 Molecular Formula: C20H11Cl2F3N2O4S Molecular Weight: 503.28

UPC:

51181607

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

N651780-25mg

CAS:

2763260-36-0

Product Size:

25mg