NVP-ACC789

NVP-ACC789 is an inhibitor of human VEGFR-1 , VEGFR-2 (mouse VEGFR-2 ), VEGFR-3 and PDGFR-β with IC 50 s of 0.38, 0.02 (0.23), 0.18, 1.4 μM, respectively.In VitroThe enzymatic kinase assays demonstrate that NVP-ACC789 is an inhibitor of human VEGFR-1, VEGFR-2 (mouse VEGFR-2), VEGFR-3 and PDGFR-β with IC 50 s of 0.38, 0.02 (0.23), 0.18, 1.4 μM, respectively. In VEGF-treated cultures, addition of the VEGFR-2 inhibitor NVP-ACC789 reduces BME cell number to baseline levels from 1 μM. Likewise, bFGF-induced BME cell proliferation is reduced markedly by NVP-ACC789 from 1 to 10 μM, without however reaching basal levels. NVP-ACC789 is found to be a potent inhibitor of VEGF-induced HUVE cell proliferation with an IC 50 of 1.6 nM. NVP-ACC789 also completely inhibits VEGF-induced BME and BAE cell invasion and VEGF-C-induced BAE cell invasion. The inhibition is dose-dependent in both cell types with a maximal effect from 1 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoNVP-ACC789 which is given in daily oral doses for 6 days blocks VEGF-induced angiogenesis in a dose-dependent manner. NVP-ACC789 also inhibits the response to bFGF to some extent, but the dose-response curve is not linear for NVP-ACC789 . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:VEGFR-2 0.02 μM (IC 50 ) VEGFR-1 0.38 μM (IC 50 ) mVEGFR-2 0.23 μM (IC 50 ) VEGFR-3 0.18 μM (IC 50 ) PDGFR-β 1.4 μM (IC 50 )

Specifications & Purity: NVP-ACC789 is an inhibitor of human VEGFR-1 , VEGFR-2 (mouse VEGFR-2 ), VEGFR-3 and PDGFR-β with IC 50 s of 0.38, 0.02 (0.23), 0.18, 1.4 μM, respectively.In VitroThe enzymatic kinase assays demonstrate that NVP-ACC789 is an inhibitor of human VEGFR-1, VEGFR-2 (mouse VEGFR-2), VEGFR-3 and PDGFR-β with IC 50 s of 0.38, 0.02 (0.23), 0.18, 1.4 μM, respectively. In VEGF-treated cultures, addition of the VEGFR-2 inhibitor NVP-ACC789 reduces BME cell number to baseline levels from 1 μM. Likewise, bFGF-induced BME cell proliferation is reduced markedly by NVP-ACC789 from 1 to 10 μM, without however reaching basal levels. NVP-ACC789 is found to be a potent inhibitor of VEGF-induced HUVE cell proliferation with an IC 50 of 1.6 nM. NVP-ACC789 also completely inhibits VEGF-induced BME and BAE cell invasion and VEGF-C-induced BAE cell invasion. The inhibition is dose-dependent in both cell types with a maximal effect from 1 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoNVP-ACC789 which is given in daily oral doses for 6 days blocks VEGF-induced angiogenesis in a dose-dependent manner. NVP-ACC789 also inhibits the response to bFGF to some extent, but the dose-response curve is not linear for NVP-ACC789 . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:VEGFR-2 0.02 μM (IC 50 ) VEGFR-1 0.38 μM (IC 50 ) mVEGFR-2 0.23 μM (IC 50 ) VEGFR-3 0.18 μM (IC 50 ) PDGFR-β 1.4 μM (IC 50 )

Grade: Moligand™

Molecular Formula: C21H17BrN4

Molecular Weight: 405.29

PubChem CID: 6918616

Isomeric SMILES: CC1=C(C=C(C=C1)NC2=NN=C(C3=CC=CC=C32)CC4=CC=NC=C4)Br

Storage Temperature: Store at -20°C

Shipped in: Ice chest + Ice pads

UPC:

51442718

Weight:

1.06 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

N649460-100mg

Country of Origin:

China

CAS:

300842-64-2

Product Size:

100mg

Harmonized Tariff Code:

2931.90.90