OLIGOMYCIN FROM STREPTOMYCES DIASTATOCHROMOGENES >=90% TOTAL OLIGOMYCINS BASIS (HPLC) (C005B-442299)

General description

Chemical structure: macrolide

Application

Oligomycin from Streptomyces diastatochromogenes is used:

• in the inhibition of mitochondrial ATP production Leigh syndrome (LS) cells.
• in ATP-linked respiration and maximal capacity respiration assay in astrocytes.
• in measurement of oxygen consumption rate (OCR) and extracellular acidification rates in breast cancer cell lines.

Biochem/physiol Actions

Oligomycin belongs to the macrolide group of antibiotics. It inhibits mitochondrial ATP-synthase enzyme and phosphoryl group transfer. Oligomycin interacts with ATP synthase subunit-c in the Fo portion and impairs proton transport.

Other Notes

A mixture of oligomycins A, B, and C.

UPC:

51102800

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

Quantity:

25

Unit of Measurement:

MG

MPN:

O4876-25MG

CAS:

1404-19-9