PDE4B-IN-3 (C007B-387066)

PDE4B-IN-3 is a potent PDE4B inhibitor with an IC 50 of 0.94 μM. PDE4B-IN-3 has anti-inflammatory activities.Appearance:SolidIC50& Target:PDE4B 0.94 μM (IC 50 )In Vitro:PDE4B-IN-3 (compound f4) has good inhibitory activity on the production of NO, TNF-α and IL-1β with IC 50 values of 20.40 μM, 23.48 μM, and 18.98 μM in RAW264.7 cells. PDE4B-IN-3 could also inhibit the expression of iNOS and COX-2 in RAW264.7 cells.In Vivo:In vivo studies shows that PDE4B-IN-3 (compound f4; 10-30mg/kg) could improve the degree of foot swelling and knee joint pathology in adjuvant-induced arthritic rats and decrease the levels of serum inflammatory factors TNF-α and IL-1β in a dose-dependenBiological Activity:PDE4B-IN-3 is a potent PDE4B inhibitor with an IC 50 of 0.94 μM. PDE4B-IN-3 has anti-inflammatory activities. Specification: 0.99 Molecular Formula: C30H35N3O4S2 Molecular Weight: 565.75

UPC:

51385301

Condition:

New

Weight:

1.09 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

P659387-100mg

Product Size:

100mg