A cyanoquinoline that irreversibly inhibits the receptor tyrosine kinases EGFR (IC50 = 39 nM) and HER2 (IC50 = 1.2 &muM) disrupts Akt and MAPK pathways, inducing apoptosis and suppressing the growth of tumor cell lines.
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A cyanoquinoline that irreversibly inhibits the receptor tyrosine kinases EGFR (IC50 = 39 nM) and HER2 (IC50 = 1.2 μM); disrupts Akt and MAPK pathways, inducing apoptosis and suppressing the growth of tumor cell lines.
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