PfDHODH-IN-2 (C007B-385806)

PfDHODH-IN-2, a dihydrothiophenone derivative (Compound 11), is a potent Plasmodium falciparum dihydroorotate dehydrogenase ( Pf DHODH) inhibitor with an IC 50 of 1.11 µM. PfDHODH-IN-2 acts as an antimalarial agent and can be used for the research of malariaIn VitroMalaria is a global parasitic infectious disease caused by Plasmodium parasites, among which Plasmodium falciparum is the most dangerous one with the highest rates of complications and mortality. PfDHODH-IN-2 shows an overall selectivity for PfDHODH (IC 50 =1.113 µM) over hDHODH (IC 50 >50 µM). PfDHODH-IN-2 demonstrats in vitro potency against the 3D7 and Dd2 strains of P. falciparum with IC 50 values of both >20 µM, respectively in whole cell assays. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:IC50: 1.113 µM (PfDHODH) IC50: >50 µM ( hDHODH). Specification: 0.99 Molecular Formula: C13H12ClNO3S Molecular Weight: 297.76 PubChem CID: 135449276 Isomeric SMILES: CCOC(=O)C1=C(CSC1=NC2=CC=C(C=C2)Cl)O

UPC:

41141618

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

WeightUOM:

LB

MPN:

P648423-100mg

CAS:

425629-94-3

Product Size:

100mg