PIP3 ANTAGONIST PITENIN-7 1PC X 10MG (C005B-229188)

General description

A cell-permeable DM-PIT-1 (Cat. No. 524619) analog that is more selective and potent than DM-PIT-1 against PH domain-mediated PIP3 (Cat. No. 524615) binding to Akt1 (IC₅₀ = 13.4 and 27.1 µM, respectively) and PDK1 (IC₅₀ = 52.3 and 80.5 µM, respectively), while being much less active than DM-PIT-1 against PIP3 GRP1 PH domain binding (12% vs 84% inhibition with 100 µM respective compound). PIT-7 is also shown to be more effective than DM-PIT-1 in inhibiting human glioblastoma U87MG survival (IC₅₀ = 6.6 vs. 33.9 µM, respectively) and cellular Akt Ser473 phosphorylation in cultures in vitro.

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Miao, B., et al. 2010. Proc. Natl. Acad. Sci. USA107, 20126.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Molecular Weight: 376.47. Empirical Formula: C₂₂H₂₀N₂O₂S. Quality Level: 100. Assay: ≥. 95% (HPLC). form: semisolid. manufacturer/tradename: Calbiochem^®. . storage condition: OK to freeze, protect from light. color: yellow-white. solubility: DMSO: 100 . mg/mL. shipped in: ambient. storage temp.: 2-8°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 2. Flash Point(F): Not applicable. Flash Point(C): Not applicable.

Shipping Information:

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UPC:

42221909

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

Quantity:

10

Unit of Measurement:

MG

MPN:

524618-10MG

Temperature Control Device:

Yes

Controlled Substances and Cyanide:

Yes