PKC? TRANSLOCATION INHIBITOR 1PC X 5MG (C15-1305-417)

General description

An octapeptide that selectively inhibits the translocation of PKC_ε to subcellular sites. Inhibition of PKC_ε translocation is known to specifically block phorbol ester or norepinephrine-mediated regulation of contraction in cardiomyocytes.

An octapeptide that selectively inhibits the translocation of protein kinase C_ε to subcellular sites in a reversible manner. Inhibition of PKC_ε translocation is known to specifically block phorbol ester- or norepinephrine-mediated regulation of contraction in cardiomyocytes.

Biochem/physiol Actions

Cell permeable: no

Primary Target
PKCε Translocation

Product does not compete with ATP.

Reversible: yes

Warning

Toxicity: Standard Handling (A)

Sequence

H-Glu-Ala-Val-Ser-Leu-Lys-Pro-Thr-OH

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Yedovitzky, M., et al. 1997. J. Biol. Chem. 272, 1417.
Johnson, J.A., et al. 1996. J. Biol. Chem.271, 24962.

Legal Information

Sold under license of U.S. Patent 5,783,405.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Molecular Weight: 843.96. Empirical Formula: C₃₇H₆₅N₉O₁₃. Quality Level: 100. Assay: ≥. 97% (HPLC). form: lyophilized solid. manufacturer/tradename: Calbiochem^®. . storage condition: OK to freeze, desiccated (hygroscopic). color: white. solubility: water: 3 . mg/mL. shipped in: ambient. storage temp.: 2-8°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.