An orally available inhibitor of native Bcr-Abl tyrosine kinase (IC50 = 0.37 nM) as well as various clinically important mutant forms including Bcr-AblT315I (IC50 = 2 nM); inhibits tumor growth in a Ba/F3 Bcr- AblT315I xenograft model of chronic myeloid leukemia in mice upon oral dosing at 10-30 mg/kg.
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- UPC:
- 51111862
- Condition:
- New
- Availability:
- 3 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 11494-10
- CAS:
- 943319-70-8
- Model Number:
- C832E46
- Temperature Control Device:
- Yes
