PROTAC Bcl2 degrader-1 (C007B-386508)

PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 ( IC 50 , 4.94 μM; DC 50 , 3.0 μM) and Mcl-1 ( IC 50 , 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1Form:SolidIC50& Target:Bcl-2 3 μM (DC 50 ) Bcl-2 4.94 μM (IC 50 ) Mcl-1 11.81 μM (IC 50 ). Specification: 0.98 Molecular Formula: C45H45BrN6O10S Molecular Weight: 941.84 PubChem CID: 139035047 Isomeric SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCNC(=O)CCCCC(=O)NCCN4C(=O)C5=C6C(=C(C=C5)SC7=CC=C(C=C7)Br)C=CC=C6C4=O

UPC:

51284139

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No;ManufacturerName=Aladdin Scientific"

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

P651231-5mg

CAS:

2378801-85-3

Product Size:

5mg

Controlled Substances and Cyanide:

Yes