PSB36 (C005B-313665)

Application

PSB36 was used to examine the role of A1-adenosine receptor-mediated cell signaling in CD39 expression in pancreatic b-cells of streptozotocin-induced diabetic mice.

Biochem/physiol Actions

Inhibition of A1 adenosine receptor by PSB36 modulates the spinal antinociception in animal models.

PSB36 is a very potent, selective antagonist of the adenosine A1 receptor. The compound selectivity (Ki) for human A1, A2A, A2B and A3 receptors is 0.7, 980, 187 and 2300 respectively. PSB36 is considerably more potent that DPCPX (EC₅₀ 0.012 nM vs 2.9 nM)

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

UPC:

51182079

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

MPN:

SML0212-10MG

CAS:

524944-72-7

Controlled Substances and Cyanide:

Yes