PYBOP 25 G

General description

The standard in situ coupling reagent for solid phase peptide synthesis ^[1,2,3,4,5]. This product can replace BOP in all applications without loss of performance. Unlike uronium-based reagents, PyBOP^® does not give rise to guanidinated by-products during cyclization and fragment condensation reactions.

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

^[1] J. Martinez, et al. (1985) J. Med. Chem., 28, 1874.
^[2] J. Coste, et al. (1990) Tetrahedron Lett., 31, 205.
^[3] G. B. Fields, et al. in ′Innovation & Perspectives in Solid Phase Synthesis, 1st International Symposium′, R. Epton (Eds), SPCC UK Ltd., Birmingham, 1990, pp. 241.
^[4] T. Høeg-Jensen, et al. (1991) Tetrahedron Lett., 32, 7617.
^[5] R. von Eggelkraut-Gottanka, et al. (2003) Tetrahedron Lett., 44, 3551.

Linkage

Replaces: 01-62-0016

Analysis Note

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

UPC:

51434800

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

MPN:

8510090025

CAS:

128625-52-5