PYZD 4409

PYZD-4409 is a specific inhibitor of the ubiquitin-activating enzyme UBA1 with an IC50 of 20 μM (cell-free enzymatic assay). PYZD-4409 induces cell death in malignant cells and preferentially inhibits the clonogenic growth of primary acute myeloid leukemia cells.

Ubiquitin-activating enzyme (E1) inhibitor

Specifications & Purity: PYZD-4409 is a specific inhibitor of the ubiquitin-activating enzyme UBA1 with an IC50 of 20 μM (cell-free enzymatic assay). PYZD-4409 induces cell death in malignant cells and preferentially inhibits the clonogenic growth of primary acute myeloid leukemia cells.

Molecular Formula: C₁₄H₇ClFN₃O₅

Molecular Weight: 351.67

EC Number: 809-458-3

PubChem CID: 60111983

Isomeric SMILES: C1=CC(=C(C=C1N2C(=O)/C(=C\C3=CC=C(O3)[N+](=O)[O-])/C(=O)N2)Cl)F

Storage Temperature: Store at -20°C

Shipped in: Ice chest + Ice pads

More Information: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/P288171-SCI_428032ec922b15f40ca66996066fa586.pdf

UPC:

51173008

Weight:

1.06 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

P288171-1mg

Country of Origin:

China

CAS:

423148-78-1

Product Size:

1mg

Harmonized Tariff Code:

2931.90.90

Health Hazards:

Toxic

Hazard Statement Codes:

H301;H315;H319;H335

Precautionary Statement Codes:

P261;P264;P270;P271;P280;P321;P330;P302+P352;P304+P340;P305+P351+P338;P362+P364;P405;P403+P233;P501;P264+P265;P301+P316;P337+P317;P332+P317;P319