Quarfloxin (C007B-414604)

Quarfloxin (CX-3543), a fluoroquinolone derivative with antineoplastic activity, targets and inhibits RNA pol I activity, with IC 50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) templateIn VitroQuarfloxin (CX-3543) effectively inhibits the growth of neuroblastoma cells in vitro. MNA (or high c-Myc) and wt-TP53 cell lines are found to be more sensitive to Quarfloxin. Quarfloxin and induces DNA damage, p53 signaling, cell death, and cell cycle arrest in neuroblastoma cell lines. Solution in vitro : Quarfloxin is suspended in DMSO to a stock of 10 mM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:RNA pol I. Specification: 0.99 Molecular Formula: C35H33FN6O3 Molecular Weight: 604.67 PubChem CID: 11635763 Isomeric SMILES: CN1CCC[C@H]1CCNC(=O)C2=CN3C4=CC5=CC=CC=C5C=C4OC6=C3C(=CC(=C6N7CCC(C7)C8=NC=CN=C8)F)C2=O

UPC:

51112704

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

Q650166-100mg

CAS:

865311-47-3

Product Size:

100mg