Quercetagetin

Quercetagetin is a cell-permeable flavanol compound that acts a potent, ATP-competitive, and reversible inhibitor of PIM1 kinase (IC50 = 340 nM). Exhibits ≥7-fold selectivity over 8 other kinases tested, including PIM2 (IC50 = 3.45 μM), and little activity toward c-Abl even at concentrations as high as 200 μM. Inhibits cellular BAD phosphorylation (IC50 = 5.5 μM) and induces growth arrest (ED50 = 3.8 μM) in PIM1-expressing RWPE2 cells.

an ATP-competitive flavanol inhibitor of Pim-1 (PIM1) kinase

Specifications & Purity: Quercetagetin is a cell-permeable flavanol compound that acts a potent, ATP-competitive, and reversible inhibitor of PIM1 kinase (IC50 = 340 nM). Exhibits ≥7-fold selectivity over 8 other kinases tested, including PIM2 (IC50 = 3.45 μM), and little activity toward c-Abl even at concentrations as high as 200 μM. Inhibits cellular BAD phosphorylation (IC50 = 5.5 μM) and induces growth arrest (ED50 = 3.8 μM) in PIM1-expressing RWPE2 cells.

Molecular Formula: C15H10O8

Molecular Weight: 318.23

PubChem CID: 5281680

Isomeric SMILES: C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C=C(C(=C3O)O)O)O)O)O

Storage Temperature: Protected from light;Store at -20°C

Shipped in: Ice chest + Ice pads

More Information: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/Q342038-SCI_5d31f06ec56bdb57d6874277a3a84633.pdf

UPC:

51303614

Weight:

1.06 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

Q342038-1mg

Country of Origin:

China

CAS:

90-18-6

Product Size:

1mg

Harmonized Tariff Code:

2931.90.90

Precautionary Statement Codes:

P264