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Sigma-Aldrich

R(+)-VERAPAMIL MONOHYDROCHLORIDE HYDRATE (C005B-284640)

Application R (+)-Verapamil monohydrochloride hydrate has been used as a P-glycoprotein (gp) inhibitor, to detect P-gp expression on the SK-OV-3 and SK-OV-3/DDP cell surface by flow cytometry. It has also been used as a calcium channel blocker,

Description

Application

R(+)-Verapamil monohydrochloride hydrate has been used as a P-glycoprotein (gp) inhibitor, to detect P-gp expression on the SK-OV-3 and SK-OV-3/DDP cell surface by flow cytometry. It has also been used as a calcium channel blocker, to evaluate its effect on doxorubicin (DOX) cytotoxicity.

Biochem/physiol Actions

Verapamil is a calcium channel blocker. Verapamil hydrochloride is a phenyl-alkyl amine derivative and is potentially used for treating hypertension, angina pectoris and arrhythmias. It is water soluble in nature.

Inhibitor of P-glycoprotein; less active enantiomer of (±)-verapamil.

Caution

hygroscopic

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Specifications
UPC:
51431614
Condition:
New
Weight:
1.00 Ounces
HazmatClass:
Yes
Quantity:
5
Unit of Measurement:
MG
MPN:
V106-5MG
CAS:
38176-02-2
Catalog No. C005B-284640
Price: $588.60
List Price: $654.00
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