(Rac)-Etavopivat (C007B-352873)

(Rac)-Etavopivat ((Rac)-FT-4202) is an isomer of Etavopivat ( HY-139573 ). Etavopivat is an orally active erythrocyte pyruvate kinase-R ( PKR ) activator that can be used in studies of sickle cell disease and other haemoglobinopathies.In VitroEtavopivat (20 μM, 4 h) improves haemoglobin-oxygen affinity and reduces the sickle point (PoS) in human red blood cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoEtavopivat (oral gavage, 3-22 mg/kg, once daily, 5 days) causes an increase in 2,3-DPG and ATP in crab-eating monkeys at doses of 8 mg/kg and 22 mg/kg . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:Solid. Specification: 0.99 Molecular Formula: C22H23N3O6S Molecular Weight: 457.5

UPC:

51131637

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

E646466-5mg

CAS:

2622070-93-1

Product Size:

5mg