Radicicol (C007B-253384)

Radicicol, a microbial cell differentiation modulator originally extracted from Neocosmospora tenuicristata, has been shown to inhibit proliferation and plasminogen activator production by vascular endothelial cells. Radicicol inhibits the expression of Cox-2 (IC50 = 27 nM) without affecting Cox-1 expression in LPS-stimulated macrophages. It is also a potent inhibitor of Hsp90. Experiments suggest that radicicol reduces the intracellular level of autophosphorylation of p60v-src as well as other tyrosine-phosphorylated proteins via inhibition of SRC kinases. In addition, radicicol has demonstrated the ability to inhibit K-ras signaling pathway which includes phosphorylation of Raf-1, MAPKK, and MAPK.A potent inhibitor of Hsp90, SRC, and Cox-2. Specification: 0.98 MDL Number: MFCD06795865 Molecular Formula: C18H17ClO6 Molecular Weight: 364.78 PubChem CID: 6323491 Isomeric SMILES: C[C@@H]1C[C@@H]2[C@H](O2)/C=C/C=C/C(=O)CC3=C(C(=CC(=C3Cl)O)O)C(=O)O1 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/R102391-SCI_a9aef23d31bde1c2820007c0850d73a4.pdf

UPC:

12352200

Condition:

New

Weight:

0.96 Ounces

HazmatClass:

Yes

WeightUOM:

LB

MPN:

R102391-1mg

CAS:

12772-57-5

Health Hazards:

Toxic

Product Size:

1mg

Hazard Statement Codes:

H301

Precautionary Statement Codes:

P261:P264:P270:P271:P280:P330:P302+P352:P304+P340:P305+P351+P338:P362+P364:P405:P403+P233:P501