Anti-HDAC1 antibody (C007B-026660)

Rabbit anti Human HDAC1 Antibody, Recombinant (RR672), could be used for WB, IHC, Flow, IF, ICC and so on.Application: WB: 1/1000 - 1/2000       IHC: 1/100 - 1/200Flow: 1/50 - 1/200IF/ICC: 1/200 - 1/500Protein FunctionResponsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Post-translationalSumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes.Ubiquitinated by CHFR, leading to its degradation by the proteasome. Specification: ExactAb™, Validated, Recombinant, High performance, 0.125 mg/mL

UPC:

41105328

Condition:

New

Weight:

1.09 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

Ab107012-50μl

Product Size:

50μl