Resatorvid (TAK-242)

InformationResatorvid (TAK-242, CLI-095) is a small-molecule-specific inhibitor ofToll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α and IL-6 in macrophages with IC50 of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulateIn vitroTAK-242 inhibits the TLR4 pathway by binding directly to a Cys747 in the intracellular TLR4 domain. TAK-242 disrupts the interactions of TLR4 with its adaptor molecules, TIRAP and TRAM.In vivoTAK-242 protects against acute cerebral ischemia/reperfusion injury in mice by dose of 3 mg/kg. Topical resatorvid can block UV-induced AP-1 activation in mouse epidermis. In a UV-induced skin tumorigenesis model, topical resatorvid displays potent photochemopreventive activity, significantly suppressing tumor area and multiplicity. Tumors harvested from resatorvid-treated mice display reduced activity of UV-associated signaling pathways and a corresponding increase in apoptosis compared to tumors from control animals. TAK-242 significantly reduces the neuronal damage occurring after cerebral ischemia, a form of stroke in mice.Cell Datacell lines：Concentrations：10 µMIncubation Time：6 hPowder Purity:≥99%. Specification: 10mM in DMSO Molecular Formula: C15H17ClFNO4S Molecular Weight: 361.82

UPC:

51111731

Condition:

New

Weight:

0.85 Ounces

HazmatClass:

No;ManufacturerName=Aladdin Scientific"

WeightUOM:

LB

MPN:

R408997-1ml

CAS:

243984-11-4

Product Size:

1ml

Controlled Substances and Cyanide:

Yes