RK-24466 (C007B-202884)

Lck Inhibitor is a cell-permeable pyrrolopyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of Lck (IC|50|at 5 μM ATP = < 1 nM, 2 nM, 70 nM, 1.57 μM and 1.98 μM for lck|64-509|Y|39|4, Lckcd pY394, Src, Kdr and Tie-2, respectively; IC|50|at 1 mM ATP = 16 μM, 66 nM, 126 nM, 420 nM and 5.18 μM for Lck64-509 Y394, Blk, Fyn, Lyn and Csk, respectively). Only minimally affects the activities of other kinases (IC|50|= 3.2 μM, > 33 μM, > 50 μM and > 50 μM for EGFR, PKC, CDC2/B and ZAP-70, respectively). Also shown to potently block T-cell receptor-stimulated IL-2 production in vitro (IC50 < 1-40 nM in Jurkat T cells). Specification: 0.98 Molecular Formula: C23H22N4O Molecular Weight: 370.45 PubChem CID: 6603792 Isomeric SMILES: C1CCC(C1)N2C=C(C3=C(N=CN=C32)N)C4=CC=C(C=C4)OC5=CC=CC=C5 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/L339695-SCI_95f358354af922ec9bcb3775b4d70859.pdf

UPC:

51343100

Condition:

New

Weight:

0.96 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

L339695-1mg

CAS:

213743-31-8

Product Size:

1mg

Precautionary Statement Codes:

P264