(S)-(+)-DIMETHINDENE MALEATE (C005B-311108)

Biochem/physiol Actions

(S)-(+)-Dimethindene maleate is an antagonist of muscarinic M2 and histamine H1 receptors, recently used as part of part of four-component chemical cocktail shown to convert pluripotent stem cells (PSCs) into extended pluripotent stem (EPS). (S)-(+)-Dimethindene is up to 40-fold more potent than the (R)-(-) enantiomer, with pKi values of 7.78 for M2, and lower affinities for M1, M3 and M4 (7.08, 6.7 and 7.0, respectively). (S)-(+)-Dimethindene has lower affinity for H1 than (R)-(-)- Dimethindene, with pA2 values of 7.48 vs. 9.42, respectively.

M2 and H1 antagonist, part of four-component chemical cocktail shown to convert pluripotent stem cells (PSCs) into extended pluripotent stem (EPS)

UPC:

51141571

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

Quantity:

5

Unit of Measurement:

MG

MPN:

SML2165-5MG

CAS:

136152-65-3