(S)-FTY720-phosphonate (C007B-355977)

FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1) , used in the research of acute inflammatory diseases such as acute lung injury.In VitroFTY720 (S)-Phosphate is an agonist of S1PR1. FTY720 (S)-Phosphate (Tys, 1 μM) maintains S1PR1 protein expression, enhances the human pulmonary artery endothelial cells barrier via S1PR1, but shows no effect on inducing ubiquitination of S1PR1. FTY720 (S)-Phosphate (0.01-50 μM) also reduces β-arrestin recruitment to S1PR1. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoFTY720 (S)-Phosphate (0.5 mg/kg, i.p.) preserves S1PR1 expression in mouse lungs, is protective in bleomycin-induced acute lung injury (ALI) and attenuates lung tissue leukocyte infiltration in bleomycin-injured mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only.IC50& Target:S1PR1. Molecular Formula: C20H36NO4P Molecular Weight: 385.48

UPC:

12352200

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

F648941-5mg

CAS:

1142015-10-8

Product Size:

5mg