SAFROLE (C005B-343033)

General description

Safrole is used as a counter irritant and for treating parasitic infections.

Application

Safrole has been used to investigate the role of aldehyde dehydrogenase 3A1 (ALDH3A1) in conferring cisplatin resistance to head and neck squamous cell carcinoma (HNSCC).

Biochem/physiol Actions

Safrole is one of the vital food¢‚¬‚‚borne phytotoxins. It is present in various natural products such as spices including anise, basil, nutmeg and pepper. It exhibits cytotoxic effect in human tongue squamous carcinoma SCC¢‚¬‚‚4 cells by promoting apoptosis via mitochondria€ and caspase¢‚¬‚‚dependent signal pathways.

Safrole is a naturally-occurring genotoxic compound found in Sassafras root and Areca (betel) quid. It is a hepatocarcinogen, and safrole-DNA adducts have also been seen in oral cancers of Areca users. Metabolites of safrole form adducts with DNA and induce chromasomal aberrations and sister chromatid exchanges.

Other Notes

Principal constituent of sassafras oil

UPC:

51112523

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

Quantity:

50

Unit of Measurement:

ML

MPN:

S9652-50ML

CAS:

94-59-7

Controlled Substances and Cyanide:

Yes