Samuraciclib hydrochloride hydrate (C007B-419297)

Samuraciclib (CT7001) hydrochloride hydrate is a potent, selective, ATP-competitive and orally active CDK7 inhibitor, with an IC 50 of 41 nM. Samuraciclib hydrochloride hydrate displays 45-, 15-, 230- and 30-fold selectivity over CDK1 , CDK2 (IC 50 of 578Appearance:SolidIC50& Target:CDK7/CycH/MAT1|41 nM (IC|50|)|CDK2/cycE1|578 nM (IC|50|)|CDK1|1.8 μM (IC|50|)|CDK4|49 μM (IC|50|)|CDK5|9.4 μM (IC|50|)|CDK6|34 μM (IC|50|)|CDK9|1.2 μM (IC|50|)In Vitro:Samuraciclib (ICEC0942; 0-10 µM; 24 hours; HCT116 cells) hydrochloride hydrate treatment promotes cell apoptosis. Samuraciclib (ICEC0942; 0-10 µM; 24 hours; HCT116 cells) hydrochloride hydrate treatment induces cell cycle arrest. Samuraciclib (IIn Vivo:Samuraciclib (ICEC0942; 100mg/kg; oral gavage; daily; for 14 days; female nu/nu-BALB/c athymic nude mice) hydrochloride hydrate treatment inhibits tumor growth by 60% at day 14, and is accompanied by highly significant reductions in PolII Ser2 and Ser5 pBiological Activity:Samuraciclib (CT7001) hydrochloride hydrate is a potent, selective, ATP-competitive and orally active CDK7 inhibitor, with an IC 50 of 41 nM. Samuraciclib hydrochloride hydrate displays 45-, 15-, 230- and 30-fold selectivity over CDK1 , CDK2 (IC 50 of 578. Specification: 0.98 Molecular Formula: C22H33ClN6O2 Molecular Weight: 552.33

UPC:

51361506

Condition:

New

Weight:

1.09 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

S659090-10mg

Product Size:

10mg