SC75741 (C007B-272564)

InformationSC75741 SC75741 is a potent NF-κB inhibitor with EC50 of 200 nM. SC75741 efficiently blocks influenza virus propagation.TargetsNF-κB (Cell-based NF-κB reporter gene assay) 200 nM(EC50)In vitroSC75741 shows immunosuppressive activity by inhibiting human PBMC proliferation with IC50 of 2.2 μM. SC75741 inhibits replication of influenza A and B viruses by inhibiting NF-κB-mediated signalling on a transcriptional level. Moreover, SC75741 shows a high barrier for development of resistant virus variants.In vivoSC75741 (15 mg/kg i.p.) reduces virus replication and cytokine expression in mice lungs after H5N1 influenza virus infection.Cell Research(from reference)Cell lines：Human PBMCs Concentrations：~50 μM Incubation Time：48 hours. Specification: 0.98 Molecular Formula: C29H23N7O2S2 Molecular Weight: 565.67 PubChem CID: 23661638 Isomeric SMILES: C1CN(CCC1C2=NC(=CS2)C(=O)NC3=NC4=C(N3)C=C(C=C4)C(=O)C5=CC=CC=C5)C6=NC=NC7=C6SC=C7

UPC:

12352202

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

S413729-100mg

CAS:

913822-46-5

Product Size:

100mg