SGC-CK2-1 (C005B-309817)

Catalog No.: C005B-309817
Mfr. No.: SML2951-5MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 5
UOM: MG

Price: $344.98

List Price: $383.31

Biochem/physiol Actions SGC-CK2-1 is a potent and highly selective casein 2 (CK2, CKII) inhibitor (CK2α:/CK2α:Ã¢â‚¬Â² IC 50 = 4.2/2.

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Description
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Biochem/physiol Actions

SGC-CK2-1 is a potent and highly selective casein 2 (CK2, CKII) inhibitor (CK2α/CK2αÃ¢â‚¬Â² IC₅₀ = 4.2/2.3 nM by cell-free enzyme assay; DYRK2 IC₅₀ = 440 nM, IC₅₀≥3.4 μM against 465 other kinases). Unlike less specific CK2 inhibitors, SGC-CK2-1 shows no antiproliferation activity in HCT116 or U-87 MG cancer cultures (up to 10 μM) despite its potent cellular activity (CK2α/CK2αÃ¢â‚¬Â² IC₅₀ = 36/16 nM by cellular NanoBRET assay).

UPC:: 51112000
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML2951-5MG
CAS:: 2470424-39-4

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