SGC-CK2-1 (C005B-309818)

Biochem/physiol Actions

SGC-CK2-1 is a potent and highly selective casein 2 (CK2, CKII) inhibitor (CK2α/CK2α€² IC₅₀ = 4.2/2.3 nM by cell-free enzyme assay; DYRK2 IC₅₀ = 440 nM, IC₅₀≥3.4 μM against 465 other kinases). Unlike less specific CK2 inhibitors, SGC-CK2-1 shows no antiproliferation activity in HCT116 or U-87 MG cancer cultures (up to 10 μM) despite its potent cellular activity (CK2α/CK2α€² IC₅₀ = 36/16 nM by cellular NanoBRET assay).

UPC:

51112000

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

Quantity:

25

Unit of Measurement:

MG

MPN:

SML2951-25MG

CAS:

2470424-39-4