SMPT (4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene) (C007B-413810)

DescriptionSMPT is a heterobifunctional sulfhydryl- and amine-reactive cross-linker. SMPT is used often for conjugating a toxin molecule to a monoclonal antibody directed against a cell-surface antigen. These immunotoxins produced with SMPT are highly potent as the cleavable disulfide imparts increased cytotoxicity compared to conjugates without a cleavable bond, such as those produced with SPDP. Also, next to the pyridine-2-thione in the spacer arm are a benzene ring and a methyl group adjacent to a carbon that hinders the disulfide bond, allowing exceptional conjugate stability in vivo. SMPT has the added benefit of being more stable to hydrolysis in aqueous solutions than other NHS cross-linkers. MDL Number: MFCD00083161 Molecular Formula: C18H16N2O4S2 Molecular Weight: 388.5 PubChem CID: 130706 Isomeric SMILES: CC(C1=CC=C(C=C1)C(=O)ON2C(=O)CCC2=O)SSC3=CC=CC=N3 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/S486538-SCI_a08e4ec1835ee65b78810c01e839323e.pdf

UPC:

12142207

Condition:

New

Weight:

0.96 Ounces

HazmatClass:

No

WeightUOM:

LB

MPN:

S486538-50mg

CAS:

112241-19-7

Product Size:

50mg

Hazard Statement Codes:

H315:H319:H335

Precautionary Statement Codes:

P261:P305+P351+P338