Sigma-Aldrich
SODIUM M-PERIODATE (C005B-375784)
General description Sodium (meta)periodate is commonly used as an oxidizing agent in organic synthesis for the oxidation of various organic substrates. It can also be used as a co-oxidant with other oxidizing reagents such as osmium tetroxide and
General description
Sodium (meta)periodate is commonly used as an oxidizing agent in organic synthesis for the oxidation of various organic substrates. It can also be used as a co-oxidant with other oxidizing reagents such as osmium tetroxide and potassium permanganate. The oxidation of sodium periodate takes place in a water medium, but an organic co-solvent is used for organic substrates that are insoluble in water.
Application
Sodium (meta)periodate can be used as an oxidizing agent for the oxidation of:
- 1,2-diols to aldehydes or ketones via oxidative cleavage. Sulfides to sulfoxides in the presence of phase transfer catalysts.
- Diaryl, dialkyl, and aryl alkyl selenides to the respective selenoxides.
- Phenols and their derivatives to corresponding quinones.
- Acylphosphoranes to α,β-dicarbonyl compounds.
It can also be used in the:
- Selective alkene epoxidation and alkane hydroxylation,·
- Oxidation of carbohydrates.
- Iodination of aromatic compounds.
Useful reagent for the oxidation of carbohydrates prior to labeling with biotin hydrazide
Features and Benefits
NaIO4 is a stable, selective, and cost-effective reagent that is capable of reacting under mild conditions.
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- UPC:
- 41116104
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- Yes
- Quantity:
- 100
- Unit of Measurement:
- GM
- MPN:
- S1878-100G
- CAS:
- 7790-28-5



