Sovesudil hydrochloride (C007B-419201)

Sovesudil (PHP-201) hydrochloride is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC 50 s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil hydrochloride lowers intraocular pressure (IOP) without inducing hypeAppearance:SolidIC50& Target:ROCK-I 3.7 nM (IC 50 ) ROCK-II 2.3 nM (IC 50 )In Vitro:Sovesudil (PHP-201) (1 μM; 60 min) hydrochloride is able to induce altered cellular behavior of human trabecular meshwork (HTM) cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In Vivo:Sovesudil (0.1%, 0.3%, and 0.5%; male New Zealand White rabbits) hydrochloride effectively reduces Intraocular Pressure (IOP) in ocular normotensive and acute hypertensive rabbits without causing distinct hyperemia. MCE has not independently confirmeBiological Activity:Sovesudil (PHP-201) hydrochloride is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC 50 s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil hydrochloride lowers intraocular pressure (IOP) without inducing hype. Specification: 0.99 Molecular Formula: C23H23ClFN3O3 Molecular Weight: 443.9

UPC:

51434007

Condition:

New

Weight:

1.09 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

S658733-10mg

Product Size:

10mg