SP-96

SP-96 is a potent, selective and non-ATP-competitive inhibitor ofAurora Bwith IC50 of 0.316 nM. SP-96 can be used for the research of triple negative breast cancer (TNBC).TargetsAurora B (Cell-free assay) 0.316 nMIn vitroSP-96 shows sub-nanomolar potency in Aurora B enzymatic assays (IC50 = 0.316 ± 0.031 nM). SP-96 shows >2000 fold selectivity against FLT3 and KIT which is important for normal hematopoiesis. Enzyme kinetics of SP-96 shows non-ATP competitive inhibition which makes it a first-in-class inhibitor. SP-96 shows selective growth inhibition in NCI60 screening, including inhibition of MDA-MD-468, a Triple Negative Breast Cancer cell line.Cell Research(from reference)Cell lines：MCF-7 cells Incubation Time：24 h

Aurora B Selective Inhibitors

Specifications & Purity: SP-96 is a potent, selective and non-ATP-competitive inhibitor ofAurora Bwith IC50 of 0.316 nM. SP-96 can be used for the research of triple negative breast cancer (TNBC).TargetsAurora B (Cell-free assay) 0.316 nMIn vitroSP-96 shows sub-nanomolar potency in Aurora B enzymatic assays (IC50 = 0.316 ± 0.031 nM). SP-96 shows >2000 fold selectivity against FLT3 and KIT which is important for normal hematopoiesis. Enzyme kinetics of SP-96 shows non-ATP competitive inhibition which makes it a first-in-class inhibitor. SP-96 shows selective growth inhibition in NCI60 screening, including inhibition of MDA-MD-468, a Triple Negative Breast Cancer cell line.Cell Research(from reference)Cell lines：MCF-7 cells Incubation Time：24 h

Molecular Formula: C25H20FN7O

Molecular Weight: 453.47

PubChem CID: 154573766

Isomeric SMILES: CN1C=C(C=N1)C2=CC3=C(C=C2)C(=NC=N3)NC4=CC(=CC=C4)NC(=O)NC5=CC(=CC=C5)F

Storage Temperature: Store at -20°C

Shipped in: Ice chest + Ice pads

More Information: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/S414446-SCI_d3a79ec608bbee76cf1f1df37e454b7c.pdf

UPC:

42241902

Weight:

1.06 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

S414446-1mg

Country of Origin:

China

CAS:

2682114-54-9

Product Size:

1mg

Harmonized Tariff Code:

2931.90.90

Hazard Statement Codes:

H302;H315;H319;H335

Precautionary Statement Codes:

P261;P280;P301+P312;P302+P352;P305+P351+P338